Active Evidence-Seeking and Diagnostic Reasoning in Large Language Models for Clinical Decision Support
Authors: Chen Zhan, Xihe Qiu, Xiaoyu Tan et al.
Summary
arXiv:2605. 22047v1 Announce Type: new Abstract: Large language models perform well on static medical examinations, yet clinical diagnosis often requires iterative evidence gathering under uncertainty.
Relevance
Read next because Active Evidence-Seeking and Diagnostic Reasoning in Large Language Models for Clinical Decision Support overlaps with clean result "LoRA persona trained on alone emits at 23.5% when a co-trained partner learns ..., vs 0% control on Qwen2.5-7B-Instruct (MODERATE confidence)", clean result "Leakage rate is a usable signal for recovering trigger-shaped phrases on Gaperon-1125-1B without knowing the hidden trigger itself (MODERATE confidence)", clean result "Language-mismatch LoRA SFT on Qwen2.5-7B leaks the trained completion language into bystander directives the model was never trained on, absent under same-language SFT (LOW confidence)". Matching terms: text, under, eval, control, full, language, model. Source: arxiv cs.AI (Artificial Intelligence).
Threat model
Potential threat/caveat for clean result "LoRA persona trained on alone emits at 23.5% when a co-trained partner learns ..., vs 0% control on Qwen2.5-7B-Instruct (MODERATE confidence)": this item discusses evaluation, benchmark.
Abstract
arXiv:2605.22047v1 Announce Type: new Abstract: Large language models perform well on static medical examinations, yet clinical diagnosis often requires iterative evidence gathering under uncertainty. Building on prior interactive evaluation efforts, we introduce an OSCE-inspired standardized patient simulator and a controlled, reproducible benchmark for active diagnostic inquiry. Across 468 cases and 15 models in our protocol, we observe that multi-turn evidence seeking reduces diagnostic accuracy by 12.75% and lowers supporting-evidence quality by 24.36% relative to full-context evaluation; error analyses associate these drops with premature diagnostic closure and inefficient questioning. Together, these results suggest that static full-context benchmarks may overestimate performance in interactive evidence-seeking settings, motivating complementary interactive assessment for safer clinical decision support.